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MERS: Introduction
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Middle East respiratory syndrome (MERS), identified recently, is a severe lung infection posing a global threat to human health. It is important to understand the nature of this disease and ways to prevent, respond to, and control outbreaks. This course provides a general introduction to MERS and is intended for incident managers and personnel working for the United Nations, international organizations and NGOs.

Self-paced Language: English Basic (Basique)
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Course information

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Overview : This course provides a general introduction to Middle East respiratory syndrome (MERS), a severe lung infection posing a global threat to human health. By the end of this course, you should be able to describe: the nature of the virus, the disease it causes, its history, and why it is a threat to human health; how to detect and assess a MERS outbreak; strategies for preventing and controlling MERS outbreaks; and what strategies should be used to communicate risk and engage communities to detect, prevent and respond to MERS. There are resources attached to each module to help you dive further into this topic, and you will take a quiz at the end of the course.

Learning objective: Understand the fundamental principles of MERS and how to effectively respond to an outbreak.

Course duration : Approximately 4 hours.

Certificates : No certificate available at this time.

If you would like to enroll for this course, there are no formal prerequisites or limitations. The course is free and open for everyone . Just register for an account on OpenWHO and go for the course!

free and open for everyone
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Unit 1: The global situation

Learners enrolled: 1344
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About OpenWHO

OpenWHO aims to equip all frontline responders with the knowledge they need to better contain disease outbreaks and manage health emergencies. It also aims to foster discussions, feedback and sharing of expert knowledge on public health.

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Figure 5.

Platelets from DAPP1 mice are hyperresponsive to collagen-driven functional responses. (A) Whole blood from WT or DAPP1 (KO) mice was loaded with DIOC6 and flowed over collagen (1000 s, 3 min) before fixation and imaging by confocal microscopy; (i) representative images of z-slices at indicated intervals relative to the thrombus base; (ii) histogram of surface coverage; (iii) histogram of thrombus height. n = 5 + standard error of the mean. (B) CRP-mediated platelet aggregation in WT and DAPP1 mouse platelets; (i) representative aggregation trace; (ii) histogram of the percentage of aggregation in response to a range of indicated CRP concentrations. n = 6 + standard error of the mean. Statistical analyses were performed by using Student tests (A) or 2-way analysis of variance with Bonferroni post-tests (B). * < .05; ** < .001.

A similar negative regulatory role for DAPP1 has been reported in mast cells, where it acts to limit FcεRI-induced granule release. Long Sleeved Swing Top White Asos Free Shipping Cheap Clearance With Mastercard Clearance Lowest Price oi81Ot
To determine whether the elevated functional responses of DAPP1 −/− platelets might correspond to a similar enhancement of granule release, we conducted fluorescence-activated cell sorting (FACS) analysis and luminometry to assess platelet secretion. Compared with wild-type controls, DAPP1 −/− platelets displayed significantly enhanced P-selectin exposure and ATP release in response to CRP ( Figure 6A-B ), confirming enhanced α and δ granule secretion, respectively. We also observed a significant increase in GPVI-mediated platelet integrin α IIb β 3 activation in the absence of DAPP1 ( get along pant Odd Molly PM44US
), which was blocked in the presence of the PI3K inhibitor, wortmannin ( Mens ThreePack Multistripe Trunks GANT Free Shipping With Mastercard Great Deals Sale Online aS3Sa
). Although DAPP1 −/− mast cells were reported to display changes in calcium mobilization and phosphorylation of AKT and ERK, 67 these parameters were not significantly altered in CRP-treated DAPP1 −/− platelets (supplemental Figure 6A-B). Similarly, we observed no significant changes to the CRP-induced phosphorylation status of proximal GPVI signaling components (supplemental Figure 7), although we did detect small but significant changes in the surface expression of GPVI and GP1bα on DAPP1 −/− platelets (supplemental Figure 8). In contrast to GPVI-mediated platelet function, we saw a modest decrease in PAR4-AP–induced platelet aggregation in DAPP1 −/− mice, whereas α and δ granule secretion and α IIb β 3 integrin activation were unchanged in response to this agonist (supplemental Figure 9). Taken together, these results reveal that the class I PI3K effector, DAPP1, restrains platelet function downstream of GPVI, thus identifying a novel negative regulator of collagen-driven platelet activation and thrombus formation.

20.5.2Remote Update

The remote client monitors your application classpath for changes in the same way as the Statement Bag Wake by VIDA VIDA w205Ej7
. Any updated resource is pushed to the remote application and ( if required ) triggers a restart. This can be helpful if you iterate on a feature that uses a cloud service that you do not have locally. Generally, remote updates and restarts are much quicker than a full rebuild and deploy cycle.

21.Packaging Your Application for Production

Executable jars can be used for production deployment. As they are self-contained, they are also ideally suited for cloud-based deployment.

For additional “production ready” features, such as health, auditing, and metric REST or JMX end-points, consider adding spring-boot-actuator . See PartV, “Spring Boot Actuator: Production-ready features” for details.

22.What to Read Next

You should now understand how you can use Spring Boot and some best practices that you should follow. You can now go on to learn about specific Spring Boot features in depth, or you could skip ahead and read about the “ production ready ” aspects of Spring Boot.

This section dives into the details of Spring Boot. Here you can learn about the key features that you may want to use and customize. If you have not already done so, you might want to read the " PartII, “Getting Started” " and " Mens Otis Boxer Shorts CALIDA Cheap Sale Fake Outlet Websites Cheap Sale Limited Edition Clearance In China MLrMFA9U
" sections, so that you have a good grounding of the basics.

23.SpringApplication

The SpringApplication class provides a convenient way to bootstrap a Spring application that is started from a main() method. In many situations, you can delegate to the static SpringApplication.run method, as shown in the following example:

When your application starts, you should see something similar to the following output:

By default, INFO logging messages are shown, including some relevant startup details, such as the user that launched the application. If you need a log level other than INFO , you can set it, as described in Section26.4, “Log Levels” ,

23.1Startup Failure

If your application fails to start, registered FailureAnalyzers get a chance to provide a dedicated error message and a concrete action to fix the problem. For instance, if you start a web application on port 8080 and that port is already in use, you should see something similar to the following message:

If no failure analyzers are able to handle the exception, you can still display the full conditions report to better understand what went wrong. To do so, you need to Womens 40CA615680155 Gladiator Sandals Black Schwarz/Silber 155 75 UK Dockers by Gerli bC4kBCm
or enable DEBUG logging for org.springframework.boot.autoconfigure.logging.ConditionEvaluationReportLoggingListener .

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